MITACS Industrial Postdoctoral Fellowship in Bioprocess Development Group at BioZone
Job ID: 2016-0520
Positions: 1
Location: BioZone, Chemical Engineering Department, University of Toronto and AbCelex Technologies Inc., Mississauga
Category: R&D
Company Overview:
AbCelex Technologies Inc. (www.abcelex.com) is a Canadian biotech company committed to the discovery & development of innovative technologies and feed additive products to prevent or treat microbial contamination in livestock, enabling the cost-effective production of safe, high-quality animal protein and meat products. AbCelex is located in Mississauga, Ontario.
BioZone (dev.biozone.utoronto.ca) is a Centre for Bioscience and Bioengineering Research at the University of Toronto. BioZone has experience with cultivation of different expression systems for large scale recombinant protein production (bioreactors up to 80-L) as well as downstream processing. Additionally, the state-of-the-art facilities at BioZone allow for protein characterization and identification. Researchers from BioZone currently have active collaboration with AbCelex including nanobody production and downstream processing optimization projects.
Job Description:
We are seeking a MITACS industrial Postdoctoral Fellow or graduate student candidate with experience in recombinant protein production and purification to join our antibody-based product development team.
The candidate must possess high degree of innovation, ability to work in a multidisciplinary and fast-paced environment, both independently and in a team setting, and working with diverse cross functional groups.
Responsibilities:
- Development and optimization of AbCelex’s recombinant antimicrobial antibody production in small scale bioreactors (5-L fermentation vessels)
- Scale-up the recombinant antibody production (80-L fermentation vessel)
- Harvesting the culture and development of downstream processing and protein purification
- Development of analytical methods for characterization of AbCelex’s recombinant antibodies
- Analyze data and prepare clear written reports on experimental results and
- Keep up-to-date with information and write clear SOPs for staff and technology transfer activities
Qualifications, Education and Experience:
The ideal candidate will have the following:
- Undergraduate degree in microbiology or bioprocess engineering (for graduate student candidates) or PhD in microbiology or other related disciplines (for PDF candidates).
- PDF candidates will have a minimum of 1-3 years of experience, preferably in production of recombinant proteins using different expression systems. Expertise on different expression systems especially Pichia pastoris is highly desirable.
- Highly experienced working with small and mid-sized bioreactor. Ability to set-up and operate fermentation and bioprocess equipment. The fermentation runs need flexibility and late/overnight shift work may be required. Ability to lift 10-25 lbs. on a frequent basis.
- Hands-on downstream processing experience including chromatography methods for protein purification and analysis.
- Excellent written, verbal, presentation skills.
- Team player with ability to interact and communicate within a multidisciplinary team.
Interested candidates:
Please email your Resume/CV with a cover letter summarizing your qualifications for this position, with referencing job ID: 2016-0520 in subject line to: emma.master@utoronto.ca
Due to the volume of responses, only qualified candidates will be considered.
No relocation. Please no agencies.
